甘露醇安全技术说明书
Product Identification
【Product Name】D-Mannitol
【Synonyms】Isotol
【CAS】69-65-8
【Formula】C6H14O6
【Molecular Weight】182.17
【EINECS】200-711-8
【RTECS】OP2060000
【RTECS Class】Tumorigen; Drug; Mutagen; Human Data
【Merck】13,5769
【Beilstein/Gmelin】1721898
【Beilstein Reference】4-01-00-02841

Physical and Chemical Properties
【Appearance】Odorless white crystalline powder or free-flowing granules. Sweet taste.
【Solubility in water】Soluble
【Melting Point】164 - 169℃
【Boiling Point】295℃
【Density】1.49 g/cm3
【pKa/pKb】13.50 (pKa)
【Partition Coefficient】-3.1
【Heat Of Vaporization】135.60 kJ/mol
【Heat Of Combustion】-3050 kJ/mol
【Usage】Used in the food industry as anti-caking and free flowing agent, stabilizer, thickener, and non-nutritive sweetener.
【Vapor Density】1.52
【Refractive Index】1.333 (20℃)

First Aid Measures
【Ingestion】If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
【Inhalation】Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
【Skin】Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
【Eyes】Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage
【Storage】Store in a cool, dry place. Keep from contact with oxidizing materials.
【Handling】Use with adequate ventilation. Avoid contact with skin and eyes. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification
【Inhalation】May cause respiratory tract irritation. Low hazard for usual industrial handling.
【Skin】May cause skin irritation. Low hazard for usual industrial handling
【Eyes】Dust may cause mechanical irritation.
【Ingestion】Ingestion of large amounts may cause gastrointestinal irritation. Expected to be a low ingestion hazard.

Exposure Controls/Personal Protection
【Personal Protection】
Eyes: Wear appropriate protective eyeglasses or chemical safety ggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to minimize contact with skin.
【Respirators】Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
【Exposure Effects】in overdose lethargy and coma have been reported in children ingesting thiazide diuretics. Altered mental status, headache, hypertonia, muscle weakness, and seizures may develop secondary to diuretic-induced electrolyte abnormalities. Ototoxicity occurs rarely and is usually reversible.
【Poison Class】-

Fire Fighting Measures
【Fire Fighting】Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Dusts at sufficient concentrations can form explosive mixtures with air. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: For small fires, use water spray, dry chemical, carbon dioxide or chemical foam.
【Fire Potential】This chemical is probably combustible.

Accidental Release Measures
【Small spills/leaks】Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity
【Incompatibilities】Oxidizing materials.
【Stability】Stable under normal shipping and handling conditions. Stable at room temperature in closed containers under normal storage and handling conditions.
【Decomposition】Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Transport Information
【HS Code】2905 43 00