L-脯氨醇安全技术说明书
Product Identification
【Product Name】S-2-Hydroxymethyl-pyrrolidine
【Synonyms】L-(Pyrrolidin-1-yl)methanol
【CAS】23356-96-9
【Formula】C5H11NO
【Molecular Weight】101.14
【EINECS】245-605-2
【Beilstein/Gmelin】79843
【Beilstein Reference】5-21-01-00077

Physical and Chemical Properties
【Appearance】Colorless viscous liquid.
【Solubility in water】Very soluble
【Boiling Point】75℃
【Density】1.025 g/cm3
【pKa/pKb】3.44 (pKb)
【Usage】Used as a chiral building block in organic synthesis.
【Vapor Density】3.49
【Refractive Index】1.4878 (20℃)

First Aid Measures
【Ingestion】Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
【Inhalation】Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
【Skin】Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
【Eyes】Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage
【Storage】Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 C). Do not expose to air. Store protected from moisture. Store under an inert atmosphere.
【Handling】Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Handle under an inert atmosphere. Store protected from air. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.

Hazards Identification
【Ingestion】May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
【Inhalation】Causes respiratory tract irritation. Aspiration may lead to pulmonary edema. Inhalation at high concentrations may cause CNS depression and asphixiation.
【Skin】Causes skin irritation. May cause irritation and dermatitis. May cause cyanosis of the extremities.
【Eyes】Causes eye irritation. May cause chemical conjunctivitis and corneal damage.
【EC Risk Phrase】R 36/38
【EC Safety Phrase】S 26 36

Exposure Controls/Personal Protection
【Personal Protection】
Eyes: Wear appropriate protective eyeglasses or chemical safety ggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
【Respirators】Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Fire Fighting Measures
【Flash Point】86℃
【Fire Fighting】Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Combustible Liquid. Extinguishing media: Use water spray to cool fire-exposed containers. Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Accidental Release Measures
【Small spills/leaks】Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. Place under an inert atmosphere.

Stability and Reactivity
【Stability】Stable at room temperature in closed containers under normal storage and handling conditions.
【Incompatibilities】Strong oxidizing agents, acid chlorides, acid anhydrides, moisture, air.
【Decomposition】Carbon monoxide, oxides of nitrogen, irritating and toxic fumes and gases, carbon dioxide.