Material Safety Data Sheet
Isoquinoline 　异喹啉
Section 1 - Chemical Product and Company Identification
MSDS Name: Isoquinoline
Catalog Numbers: 32503-0000, 32503-0050, 32503-1000, 32503-5000
Synonyms:
Company Identification: Acros Organics BVBA
Janssen Pharmaceuticalaan 3a
2440 Geel, Belgium
Company Identification: (USA) Acros Organics
One Reagent Lane
Fair Lawn, NJ 07410
For information in the US, call: 800-ACROS-01
For information in Europe, call: +32 14 57 52 11
Emergency Number, Europe: +32 14 57 52 99
Emergency Number US: 201-796-7100
CHEMTREC Phone Number, US: 800-424-9300
CHEMTREC Phone Number, Europe: 703-527-3887
Section 2 - Composition, Information on Ingredients
CAS# Chemical Name: % EINECS#
119-65-3 Isoquinoline 97% 204-341-8
Hazard Symbols: T

Risk Phrases: 22 24 38
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Harmful if swallowed. Toxic in contact with skin. Irritating to skin.Hygroscopic (absorbs moisture from the air).Light sensitive.
Potential Health Effects
Eye: May cause eye irritation.
Skin: Causes skin irritation. Toxic in contact with skin.
Ingestion: Harmful if swallowed. May cause irritation of the digestive tract.
Inhalation: May cause respiratory tract irritation. May cause irritation of the respiratory tract with burning pain in the nose and throat, coughing, wheezing, shortness of breath and pulmonary edema. Inhalation may be fatal as a result of spasm, inflammation, edema of the larynx and bronchi, chemical pneumonitis and pulmonary edema.
Chronic:
Section 4 - First Aid Measures
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Get medical aid. Wash mouth out with water.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Section 5 - Fire Fighting Measures
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
Section 6 - Accidental Release Measures
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Do not let this chemical enter the environment.
Section 7 - Handling and Storage
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Storage: Store in a cool, dry place. Store in a tightly closed container.
Section 8 - Exposure Controls, Personal Protection
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits
CAS# 119-65-3:

Personal Protective Equipment
Eyes: Wear chemical splash ggles.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - Physical and Chemical Properties

Physical State: Solid
Color: light brown
Odor: Not available
pH: Not available
Vapor Pressure: Not available
Viscosity: 3.25 @cP deg C
Boiling Point: 242 deg C @760mmHg ( 467.60°F)
Freezing/Melting Point: 24 - 28 deg C
Autoignition Temperature: Not available
Flash Point: 107 deg C ( 224.60 deg F)
Explosion Limits: Lower: Not available
Explosion Limits: Upper: Not available
Decomposition Temperature: Not available
Solubility in water: practically insoluble
Specific Gravity/Density: 1.090
Molecular Formula: C9H7N
Molecular Weight: 129.16
Section 10 - Stability and Reactivity
Chemical Stability: Hygroscopic: absorbs moisture or water from the air.
Conditions to Avoid: Incompatible materials, exposure to moist air or water.
Incompatibilities with Other Materials Strong oxidizing agents, strong acids.
Hazardous Decomposition Products Carbon monoxide, oxides of nitrogen, carbon dioxide.
Hazardous Polymerization Has not been reported.
Section 11 - Toxicological Information
RTECS#: CAS# 119-65-3: NW6825000

LD50/LC50: RTECS:
CAS# 119-65-3: Draize test, rabbit, skin: 20 mg/24H Moderate;
Oral, rat: LD50 = 360 mg/kg;
Skin, rabbit: LD50 = 590 uL/kg;
.
Other: Skin, rat: LD50 = 180 mg/kg
Carcinogenicity: Isoquinoline - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.

Other: The toxicological properties have not been fully investigated. See actual entry in RTECS for complete information.
Section 12 - Ecological Information
Other: Do not empty into drains.

Section 13 - Disposal Considerations
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - Transport Information

IATA IMO RID/ADR
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.* TOXIC SOLID, ORGANIC, N.O.S. TOXIC SOLID, ORGANIC, N.O.S.
Hazard Class: 6.1 6.1 6.1
UN Number: 2811 2811 2811
Packing Group: II II II

Section 15 - Regulatory Information
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T
Risk Phrases:
R 22 Harmful if swallowed.
R 24 Toxic in contact with skin.
R 38 Irritating to skin.

Safety Phrases:
S 36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

WGK (Water Danger/Protection)
CAS# 119-65-3: Not available

Canada
CAS# 119-65-3 is listed on Canada's DSL List

US Federal
TSCA
CAS# 119-65-3 is listed on the TSCA Inventory.